动物研究中的剂量反应分析：人类反应的预测
Dose-response analysis in animal studies: prediction of human responses.
作者信息
Alarie Y
出版信息
Environ Health Perspect. 1981 Dec;42:9-13. doi: 10.1289/ehp.81429.
Abstract
An animal bioassay has been used to evaluate a series of airborne chemicals for their sensory irritating properties to the upper respiratory tract. Teh results obtained can be used to rank their potency. An attempt has been made to predict "safe" levels of exposure for humans on the basis of this short-term assay. A good correlation was obtained between the predicted "safe" levels of exposure and current Threshold Limit Values established for industrial exposures.
摘要
一种动物生物测定法已被用于评估一系列空气传播化学物质对上呼吸道的感官刺激特性。所获得的结果可用于对它们的效力进行排名。已尝试根据这种短期测定法预测人类的“安全”接触水平。在预测的“安全”接触水平与为工业接触确定的当前阈限值之间获得了良好的相关性。
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