[氧硫胺素和吡硫胺素对大鼠血液、肝脏及尿液中硫胺素水平的影响（作者译）]

[Effect of oxythiamine and pyrithiamine on thiamine levels in the blood, liver and urine of rats (author's transl)].

作者信息

Hobara R, Okazaki M, Yasuhara H, Sakamoto K

出版信息

Nihon Yakurigaku Zasshi. 1981 Dec;78(6):529-38. doi: 10.1254/fpj.78.529.

DOI:10.1254/fpj.78.529

Abstract

Thiamine (T) deficient state and various functional and morphological changes in rat liver were induced, after several days, with T antagonists, oxythiamine (OT) or pyrithiamine (PT), and a thiamine deficient diet (TDD). The relationship between the extent of liver damage and T levels in blood, liver and urine were studied in OT treated rats fed a TDD (OTD group). PT treated rats fed a TDD (PTD group), OT treated rats (OT group), PT treated rats (PT group) and rats fed a TDD (TDD group). The T levels in blood and liver of OT group, PT group, OTD group, PTD group and TDD group were 89% and 91%, 76% and 88%, 25% and 14%, 33% and 16%, 24% and 15% compared with the data in the control group, respectively. Effects of OT or PT on T levels were not remarkable in some cases, and such may be due to the duration time of T antagonists, which was considered to be 3-15 hours in PT treated rats, and 0-18 hours in PT treated rats, as assessed by urinary T measurements. Treatment of T antagonist twice daily is recommended to obtain a definite T deficient state. Our results suggest that the extent of liver damage is related to the T levels in tissue.

摘要

用硫胺素（T）拮抗剂、氧硫胺素（OT）或吡硫胺素（PT）以及硫胺素缺乏饮食（TDD）诱导大鼠出现硫胺素（T）缺乏状态以及肝脏的各种功能和形态变化。在喂食TDD的OT处理大鼠（OTD组）、喂食TDD的PT处理大鼠（PTD组）、OT处理大鼠（OT组）、PT处理大鼠（PT组）以及喂食TDD的大鼠（TDD组）中，研究了肝脏损伤程度与血液、肝脏和尿液中T水平之间的关系。与对照组数据相比，OT组、PT组、OTD组、PTD组和TDD组血液和肝脏中的T水平分别为对照组的89%和91%、76%和88%、25%和14%、33%和16%、24%和15%。在某些情况下，OT或PT对T水平的影响并不显著，这可能是由于T拮抗剂的作用持续时间，通过尿T测量评估，PT处理大鼠的作用持续时间被认为是3 - 15小时，OT处理大鼠的作用持续时间为0 - 18小时。建议每天两次给予T拮抗剂治疗以获得明确的T缺乏状态。我们的结果表明，肝脏损伤程度与组织中的T水平有关。