35s incorporation in rats in relation to deprivation of copper and zinc in the diet.

Experiments were designed to explore connective tissue metabolism in rats eating a diet low in copper (Cu) and a diet low in zinc (Zn). Incorporation of 35S given as inorganic sulphate served as the metabolic marker. Sulphur uptake was elevated about 100% over normal in tissues of rats eating a low Cu diet: lung, kidney, spleen, aorta, small intestine, cartilage, and bone. Rats eating a diet low in Zn had levels of radioactive sulphate two to fourfold higher than normals in lung, stomach, liver, adrenal, kidney, brain, spleen aorta, thymus, skin, muscle, intestine, testes, cartilage, and bone.