Moriguchi T, Fujimoto D
J Biochem. 1978 Oct;84(4):933-5. doi: 10.1093/oxfordjournals.jbchem.a132206.
Pyridinoline is a crosslinking amino acid of collagen fibers. The age-related changes in the content of pyridinoline were followed for collagens from human and rat costal cartilage and Achilles tendon. The pyridinoline content of the collagens in fetal or newborn animals was very low and increased markedly with growth of the animals. In rat tissues, the pyridinoline content continued to increase after the animal had reached maturity. On the other hand, in human tissues, it began to decrease after about 30 years of age. Pyridinoline may serve as an interesting index for the aging of connective tissues.
吡啶啉是胶原纤维的一种交联氨基酸。对来自人和大鼠肋软骨及跟腱的胶原蛋白中吡啶啉含量随年龄的变化进行了跟踪研究。胎儿或新生动物胶原蛋白中的吡啶啉含量非常低，并随着动物生长而显著增加。在大鼠组织中，动物成熟后吡啶啉含量仍持续增加。另一方面，在人体组织中，大约30岁后它开始下降。吡啶啉可能是结缔组织老化的一个有趣指标。
