Smethurst M, Bishun N P, Fernandez D, Allen J, Burn J I, Alaghband-Zadeh J, Williams D C
J Endocrinol Invest. 1981 Oct-Dec;4(4):455-7. doi: 10.1007/BF03348311.
Cytosol and nuclear estrogen receptors and cytosol progesterone receptors were measured in 17 primary breast tumors and compared with sex chromatin frequencies. In cases with sex chromatin frequencies of greater than 20% there were 7/7 tumors with cytosol estrogen and progesterone receptors, 6/7 with cytosol and nuclear estrogen receptors, and 6/7 with all 3 receptors. This high proportion of receptor positive cases was not observed at lower sex chromatin frequencies. Sex chromatin frequencies in all the cytosol estrogen and progesterone receptor positive tumors were significantly higher (p less than 0.05) than in the other groups. Our results suggest a possible association between the presence of steroid hormone receptors and sex chromatin frequencies of greater than 20%.
在17例原发性乳腺癌中检测了胞质和核雌激素受体以及胞质孕酮受体，并与性染色质频率进行了比较。在性染色质频率大于20%的病例中，7/7的肿瘤有胞质雌激素和孕酮受体，6/7有胞质和核雌激素受体，6/7有所有三种受体。在较低的性染色质频率下未观察到如此高比例的受体阳性病例。所有胞质雌激素和孕酮受体阳性肿瘤的性染色质频率显著高于其他组（p<0.05）。我们的结果表明，类固醇激素受体的存在与大于20%的性染色质频率之间可能存在关联。
