Shelton J D, Jacobson J E, Orenstein W A, Schulz K F, Donnell H D
Pediatrics. 1978 Dec;62(6):961-4.
To evaluate the recent decision of the Advisory Committee on Immunization Practice to increase the recommended age for initial measles vaccination from 12 to 15 months, we carried out a case control study of vaccine failure in a recent measles epidemic. Compared to children vaccinated at ages 15 months or older, we found an increased risk of vaccine failure among those vaccinated at 12 to 14 months (relative risk = 19.2, 95% confidence interval = 4.6 to 80.1). In order to sort out the influence of age at vaccination from elapsed time since vaccination, we subjected the data to discriminant analysis. Age at vaccination subsumed all of the effect of duration of time since vaccination. Thus, we find no evidence of waning immunity over time.
为评估免疫实践咨询委员会最近将麻疹初次接种建议年龄从12个月提高到15个月的决定，我们针对近期一次麻疹流行期间的疫苗接种失败情况开展了一项病例对照研究。与15个月及以上接种疫苗的儿童相比，我们发现12至14个月接种疫苗的儿童出现疫苗接种失败的风险增加（相对风险=19.2，95%置信区间=4.6至80.1）。为了区分接种疫苗时的年龄和自接种以来经过的时间的影响，我们对数据进行了判别分析。接种疫苗时的年龄涵盖了自接种以来时间长短的所有影响。因此，我们没有发现免疫力随时间推移而减弱的证据。
