Tuck R R, McLeod J G
J Neurol Neurosurg Psychiatry. 1981 Nov;44(11):983-90. doi: 10.1136/jnnp.44.11.983.
The following tests of autonomic function were performed on seven patients with the Guillain-Barré syndrome and compared with controls: (1) measurement of heart rate and blood pressure in the supine and erect positions, (2) measurement of baroreflex sensitivity, (3) Valsalva's manoeuvre, (4) sweat test. In two patients the heart rates were fixed and greater than 100/min and in three there was postural hypotension. The baroflex sensitivity of four patients was abnormal and heart rate response to Valsalva's manoeuvre was impaired in two of the three patients who were able to perform the manoeuvre. Areas of anhidrosis were found in all seven patients. These abnormalities probably reflect pathological alterations of the sympathetic and parasympathetic components of the autonomic nervous system of patients with Guillain-Barré syndrome. The severity of autonomic involvement is not related to the degree of sensory and motor disturbance which is consistent with the patchy distribution of lesions throughout the peripheral and autonomic nervous systems.
对7例吉兰-巴雷综合征患者进行了以下自主神经功能测试，并与对照组进行比较：（1）测量仰卧位和直立位的心率和血压；（2）测量压力反射敏感性；（3）瓦尔萨尔瓦动作；（4）发汗试验。2例患者心率固定且大于100次/分钟，3例有体位性低血压。4例患者的压力反射敏感性异常，在能够完成瓦尔萨尔瓦动作的3例患者中，2例对该动作的心率反应受损。7例患者均发现有无汗区域。这些异常可能反映了吉兰-巴雷综合征患者自主神经系统交感和副交感神经成分的病理改变。自主神经受累的严重程度与感觉和运动障碍的程度无关，这与病变在周围和自主神经系统中的散在分布是一致的。
