Kunitomo M, Kinoshita K, Bandô Y
J Pharmacobiodyn. 1981 Sep;4(9):718-23. doi: 10.1248/bpb1978.4.718.
Atherosclerotic lesions of the aorta and coronary arteries were induced in rats fed a diet supplemented with cholesterol and vitamin D2 for 8 weeks. Rats fed a purified diet supplemented with 1% cholesterol and 1.25 million units of vitamin D2/kg of diet showed cholesterol deposition in the aorta but no abnormal findings were observed either macroscopically or microscopically in the aorta and coronary arteries. Rats fed a diet supplemented with 1.5% cholesterol and 1.8 million units of vitamin D2/kg of diet showed no only marked deposition of cholesterol and calcium but also extensive macroscopic lesions of atherosclerosis in the aorta and coronary arteries. No significant deposition of cholesterol and calcium in the aorta of rats fed the diet without the vitamin D2 supplement was observed in either experiment.
给大鼠喂食添加胆固醇和维生素D2的饲料8周，可诱发主动脉和冠状动脉的动脉粥样硬化病变。喂食添加1%胆固醇和125万单位维生素D2/千克饲料的纯化饲料的大鼠，主动脉出现胆固醇沉积，但在主动脉和冠状动脉中，无论是宏观还是微观观察均未发现异常。喂食添加1.5%胆固醇和180万单位维生素D2/千克饲料的大鼠，不仅主动脉和冠状动脉有明显的胆固醇和钙沉积，还出现了广泛的动脉粥样硬化宏观病变。在任一实验中，喂食不含维生素D2补充剂饲料的大鼠主动脉均未观察到明显的胆固醇和钙沉积。
