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血液学正常的人类骨髓和淋巴细胞中的自发及白消安诱导的姐妹染色单体交换（SCE）频率。

Spontaneous and busulphan-induced sister-chromatid exchange (SCE) frequencies in haematologically normal human bone marrow and lymphocytes.

作者信息

Honeycombe J R

出版信息

Mutat Res. 1981 Dec;84(2):399-407. doi: 10.1016/0027-5107(81)90207-4.

DOI:10.1016/0027-5107(81)90207-4
PMID:7335103
Abstract

In a study of 14 patients who were not treated with either chemotherapy or irradiation, 13 patients had lower sister-chromatid exchange (SCE) frequencies in their bone-marrow cells than in their lymphocytes. For both bone marrow and lymphocytes, there was significant inter-patient variability in SCE frequencies, but there was no correlation between the bone-marrow and lymphocyte values. The effect of exposing bone-marrow cells to busulphan (BUS) in vitro was investigated using doses up to 5.0 microgram/ml. The dose-response relationships between BUS and SCEs in vitro were found to be similar for bone marrow and lymphocytes.

摘要

在一项针对14名未接受化疗或放疗的患者的研究中，13名患者骨髓细胞中的姐妹染色单体交换（SCE）频率低于淋巴细胞中的频率。对于骨髓和淋巴细胞，患者间SCE频率均存在显著差异，但骨髓和淋巴细胞的值之间无相关性。使用高达5.0微克/毫升的剂量研究了体外将骨髓细胞暴露于白消安（BUS）的效果。发现体外BUS与SCE之间的剂量反应关系在骨髓和淋巴细胞中相似。

相似文献

1
Spontaneous and busulphan-induced sister-chromatid exchange (SCE) frequencies in haematologically normal human bone marrow and lymphocytes.血液学正常的人类骨髓和淋巴细胞中的自发及白消安诱导的姐妹染色单体交换（SCE）频率。
Mutat Res. 1981 Dec;84(2):399-407. doi: 10.1016/0027-5107(81)90207-4.
2
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