正常人骨髓细胞中姐妹染色单体交换率。
The rate of sister chromatid exchange in normal human bone marrow cells.
作者信息
Becher R, Schmidt C G, Theis G, Hossfeld D K
出版信息
Hum Genet. 1979;50(2):213-6. doi: 10.1007/BF00390243.
PMID:511136
Abstract
Sister chromatid exchange (SCE) was studied in bone marrow cells of six healthy individuals. Compared with peripheral blood lymphocytes, a remarkably low and constant rate of SCEs was observed, ranging from 3.64 to 4.65 per metaphase. The lower incidence of SCE can be related only partly to the higher contraction of bone marrow cells and the shorter exposure time to BUdR. Rather, a cell-specific phenomenon is suggested.
摘要
对6名健康个体的骨髓细胞进行了姐妹染色单体交换（SCE）研究。与外周血淋巴细胞相比，观察到SCE的发生率极低且恒定，每个中期的SCE发生率在3.64至4.65之间。SCE发生率较低仅部分与骨髓细胞较高的收缩率和较短的溴脱氧尿苷（BUdR）暴露时间有关。相反，提示这是一种细胞特异性现象。
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