Cohadon F
Neurochirurgie. 1981;27(5):241-5.
Our hypotheses concerning the pathogenesis of gliomas are based upon the study of numerous animal models. Malignant transformation is probably related to changes in the genome of somatic cells, caused either by chemical or physical agents or by the addition of viral material. Promotion of the tumor, which results in its clinical expression, would involve the failure of a hypothetical immune mechanism of surveillance. At the present time, we have no direct proof of the intervention of such various initiation or tumor-promotion factors in the pathogenesis of human gliomas.
我们关于神经胶质瘤发病机制的假说基于对众多动物模型的研究。恶性转化可能与体细胞基因组的变化有关，这些变化由化学或物理因素或病毒物质的加入引起。肿瘤的进展，即导致其临床症状的出现，可能涉及一种假设的免疫监视机制的失效。目前，我们没有直接证据表明这些不同的启动或促肿瘤因素在人类神经胶质瘤发病机制中发挥了作用。
