Wisløff F, Godal H C
Scand J Haematol. 1981 Jul;27(1):45-50. doi: 10.1111/j.1600-0609.1981.tb00450.x.
100 patients with a modified Ivy bleeding time longer than 10 min in the presence of more than 80 x 10(9)/l blood platelets were studied retrospectively. 72 patients had repeated bleeding times between 10 and 20 min or one or more measurements exceeding 20 min, and were considered to have an unquestionable platelet dysfunction. 39 (54%) of these 72 patients were receiving large doses of antibiotics. Nearly one half of the patients on antibiotics had a bleeding tendency, but most of these patients had additional features that may have interfered with platelet function, or a coagulation defect. In the remaining 33 patients, the prolonged bleeding time was associated with von Willebrand's disease, liver disease, leukaemia/myeloproliferative disease, paraproteinaemia or aspirin ingestion. High doses of penicillin seem to be the most common cause of qualitative platelet disorders in general hospital practice.
对100例血小板计数超过80×10⁹/L且改良Ivy出血时间超过10分钟的患者进行了回顾性研究。72例患者的重复出血时间在10至20分钟之间，或有一次或多次测量超过20分钟，被认为存在明确的血小板功能障碍。这72例患者中有39例（54%）正在接受大剂量抗生素治疗。近一半接受抗生素治疗的患者有出血倾向，但这些患者大多数还有可能干扰血小板功能或存在凝血缺陷的其他特征。在其余33例患者中，出血时间延长与血管性血友病、肝病、白血病/骨髓增殖性疾病、副蛋白血症或服用阿司匹林有关。在综合医院实践中，高剂量青霉素似乎是导致血小板质量异常最常见的原因。
