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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Rafter J J, Nilsson L

Xenobiotica. 1981 Nov;11(11):771-8. doi: 10.3109/00498258109045881.

The urine of conventional and germ-free rats was examined, after an oral dose of caffeine, with regard to the presence of sulphur-containing conjugates of this compound. 2. Only the methyl sulphoxide analogue was detected. 3. The ratio of the quantities of this metabolite in conventional and germ-free rat urine was 42:1. 4. The proposed mechanism for the formation of the methyl sulphoxide analogue of caffeine involves the biliary excretion of a mercapturic acid pathway metabolite of caffeine with subsequent metabolism by the intestinal microflora.

给常规饲养和无菌饲养的大鼠口服一剂咖啡因后，检测其尿液中该化合物含硫结合物的存在情况。2. 仅检测到了甲基亚砜类似物。3. 这种代谢物在常规饲养大鼠尿液和无菌饲养大鼠尿液中的量之比为42:1。4. 咖啡因甲基亚砜类似物的形成机制推测为，咖啡因的一种巯基尿酸途径代谢物经胆汁排泄，随后由肠道微生物群进行代谢。

Rafter J J, Nilsson L

Xenobiotica. 1981 Nov;11(11):771-8. doi: 10.3109/00498258109045881.

The urine of conventional and germ-free rats was examined, after an oral dose of caffeine, with regard to the presence of sulphur-containing conjugates of this compound. 2. Only the methyl sulphoxide analogue was detected. 3. The ratio of the quantities of this metabolite in conventional and germ-free rat urine was 42:1. 4. The proposed mechanism for the formation of the methyl sulphoxide analogue of caffeine involves the biliary excretion of a mercapturic acid pathway metabolite of caffeine with subsequent metabolism by the intestinal microflora.

给常规饲养和无菌饲养的大鼠口服一剂咖啡因后，检测其尿液中该化合物含硫结合物的存在情况。2. 仅检测到了甲基亚砜类似物。3. 这种代谢物在常规饲养大鼠尿液和无菌饲养大鼠尿液中的量之比为42:1。4. 咖啡因甲基亚砜类似物的形成机制推测为，咖啡因的一种巯基尿酸途径代谢物经胆汁排泄，随后由肠道微生物群进行代谢。