Takeuchi S
Am J Reprod Immunol (1980). 1980;1(1):23-8. doi: 10.1111/j.1600-0897.1980.tb00006.x.
Our study of the sequence of morphological events leading to the formation of hydatidiform mole (HM) led us to this study. Our object in this paper is to present evidence supporting our 1971 hypothesis with results obtained by various immunological methods in our laboratory, and to propose the importance of an immunoregulatory mechanism by blocking antibody (BA). Our hypothesis is that the conceptus, after the early demise of the embryo, may be dropped out in most cases as spontaneous abortion (SpA), and the trophoblast in the remaining cases continues to grow, developing into HM by an "immune selection" mechanism. Our conclusion is that the trophoblast will be damaged by immune cytotoxic mechanism through a decrease of BA in SpA, and continue to grow in HM through continuous production of BA after the demise of the embryo.
我们对导致葡萄胎（HM）形成的形态学事件序列的研究促使我们开展了本项研究。本文的目的是用我们实验室通过各种免疫学方法获得的结果来提供支持我们1971年假说的证据，并提出封闭抗体（BA）免疫调节机制的重要性。我们的假说是，胚胎早期死亡后，大多数情况下孕体可能会作为自然流产（SpA）排出，而其余情况下滋养层会继续生长，通过“免疫选择”机制发展为HM。我们的结论是，在SpA中，滋养层会因BA减少而受到免疫细胞毒性机制的损伤，而在胚胎死亡后，通过BA的持续产生，滋养层在HM中继续生长。
