[通过皮内试验评估小牛胸腺提取物对老年人细胞介导免疫的诱导变化]

[Changes induced by calf thymus extract on cell-mediated immunity, evaluated by intradermal tests, in the elderly].

作者信息

Di Feliciantonio R, Trentini M

出版信息

Boll Soc Ital Biol Sper. 1981 Dec 30;57(24):2486-92.

Abstract

A thymic calf extract (LEUCOTROFINA) was injected twice a day for 20 days to 24 elderly patients, in order to establish its efficacy to improve the lymphocytic "memory" against the antigens commonly used in the skin tests (Candidin, Tuberculin, Varidase, Mumps, Trichophytin) and the DNCB test. As far as the recall antigens were concerned, no remarkable improvement was observed in patients over 75 years, while a significant positive response (from 47% to 84,6%- P less than 0,05) was noticed in patients treated with leucotrophina aged between 65 and 75 years, compared to not treated control group. With DNCB test no difference was noted in both groups. Our data confirmed the interesting role of a thymic extract therapy in elderly patients.

摘要

对24名老年患者每天注射两次胸腺小牛提取物（白细胞生成素），持续20天，以确定其对改善针对皮肤试验常用抗原（念珠菌素、结核菌素、枯草杆菌蛋白酶、腮腺炎、毛癣菌素）和二硝基氯苯试验的淋巴细胞“记忆”的疗效。就回忆抗原而言，75岁以上患者未观察到明显改善，而与未治疗的对照组相比，接受白细胞生成素治疗的65至75岁患者有显著的阳性反应（从47%至84.6%，P小于0.05）。在二硝基氯苯试验中，两组未观察到差异。我们的数据证实了胸腺提取物疗法在老年患者中的有趣作用。