对口服给予斯普拉格-道利大鼠的含咖啡因水溶液中苯并(a)芘致瘤反应的研究。
Investigation of the tumorigenic response to benzo(a)pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats.
作者信息
Brune H, Deutsch-Wenzel R P, Habs M, Ivankovic S, Schmähl D
出版信息
J Cancer Res Clin Oncol. 1981;102(2):153-7. doi: 10.1007/BF00410666.
Abstract
In a lifetime experiment benzo(a)pyrene (B(a)P) was administered to Sprague-Dawley rats either as an admixture to the diet or by gavage in an aqueous 1.5% caffeine solution. Dissolved benzo(a)pyrene induced more tumors of the forestomach than undissolved benzo(a)pyrene. The 1.5% caffeine solution (annual dose 27 g/kg) did not exert any carcinogenic activity under the conditions of this bioassay.
摘要
在一项终生实验中，将苯并(a)芘（B(a)P）以混入饲料的形式或通过用1.5%咖啡因水溶液灌胃的方式给予斯普拉格-道利大鼠。溶解的苯并(a)芘比未溶解的苯并(a)芘诱发更多的前胃肿瘤。在本生物测定条件下，1.5%咖啡因溶液（年剂量27 g/kg）未表现出任何致癌活性。
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