Reale E, Benazzo F, Ruggeri A
J Submicrosc Cytol. 1981 Apr;13(2):135-43.
The microfibrillar arrangement of collagen fibrils has been studied on replicas of freeze-fractured specimens and on thin sections of specimens treated with a 4.0 M guanidinium chloride solution. Collagen fibrils with straight arrangement of their microfibrils usually have a variable diameter and correspond in their distribution to genetical type I and type II collagens. Collagen fibrils with helicoidal arrangement of their microfibrils present a relatively small and uniform diameter and show a tissue distribution similar to that of the genetical type III collagen. The corneal stroma, although predominantly composed of type I collagen, displays collagen fibrils with a helicoidal microfibrillar arrangement, and small uniform diameter. This exception can be explained in consideration of the function of the collagen of the corneal stroma. A close correlation between all the different microfibrillar patterns of the collagen fibrils and their function in the anatomical sites we examined is evident.
已通过冷冻断裂标本的复制品以及用4.0M氯化胍溶液处理的标本薄片，对胶原纤维的微原纤维排列进行了研究。微原纤维呈直线排列的胶原纤维通常直径可变，其分布与遗传I型和II型胶原相对应。微原纤维呈螺旋排列的胶原纤维直径相对较小且均匀，其组织分布与遗传III型胶原相似。角膜基质虽然主要由I型胶原组成，但显示出微原纤维呈螺旋排列且直径均匀细小的胶原纤维。考虑到角膜基质胶原的功能，这种例外情况可以得到解释。在我们检查的解剖部位，胶原纤维的所有不同微原纤维模式与其功能之间存在明显的密切相关性。
