Daicker B C, Kreuzer G
Klin Monbl Augenheilkd. 1981 Nov;179(5):322-9. doi: 10.1055/s-2008-1057321.
Resection of an orbital meningioma in a 53-year-old patient caused an occlusion of the central retinal artery and total ophthalmoplegia. Eight weeks postoperatively rapid development of a black disc was observed with migration of pigment into the juxtapapillary retina. One year later the eye was removed during a radical reoperation. Histological and ultrastructural examination showed that the melanosis of the disc and the retina was apparently due to reactive proliferation of the juxtapapillary pigment epithelium which had migrated into the atrophic tissues of the retina and the disc. The histological differentiation from hamartomatous proliferations of the juxtapapillary pigment epithelium is discussed. The proliferated pigment epithelium cells in this patient resemble those described in epiretinal membranes apart from abundant RER and actin filaments. In the absence of mechanical or inflammatory factors it must be assumed that hypoxia was the stimulus responsible for the proliferation. The presence of fenestrated retinal capillaries in the proliferation zone is described and the significance of this finding is discussed.
一名53岁患者的眼眶脑膜瘤切除术后导致视网膜中央动脉闭塞和完全性眼肌麻痹。术后8周，观察到视盘迅速变黑，色素迁移至视盘旁视网膜。一年后，在根治性再次手术中摘除了眼球。组织学和超微结构检查显示，视盘和视网膜的黑素沉着显然是由于视盘旁色素上皮的反应性增生，该色素上皮已迁移至视网膜和视盘的萎缩组织中。讨论了与视盘旁色素上皮错构瘤性增生的组织学鉴别。该患者增生的色素上皮细胞除了有丰富的粗面内质网和肌动蛋白丝外，与视网膜前膜中描述的细胞相似。在没有机械或炎症因素的情况下，必须假定缺氧是导致增生的刺激因素。描述了增生区域有窗孔的视网膜毛细血管的存在，并讨论了这一发现的意义。
