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[人类肾癌低温灌注的代谢与循环方面]

[Metabolic and circulatory aspects of hypothermic perfusion of human kidney cancers].

作者信息

Kleist H, Hultborn R, Jonsson O, Lundstam S, Nauclér J, Pettersson S, Scherstén I, Weiss L

出版信息

Z Urol Nephrol. 1981 Dec;74(12):883-6.

PMID:7340290
Abstract

In this study a report is made on the hypothermal perfusion of 15 renal tumours. Protein synthesis by incorporation of 14C leucine, lipide synthesis by conversion of 14C mevalonic acid and the activity of the sodium-potassium pump by incubation of sections of tissue were used as parameters of the vitality of the tissue. Circulation was studied before and after perfusion by means of angiography and the microsphere technique. After 6 days of perfusion the tumour tissue is found to be less vital in comparison with the renal cortex.

摘要

本研究报告了15例肾肿瘤的低温灌注情况。通过掺入¹⁴C亮氨酸进行蛋白质合成、通过¹⁴C甲羟戊酸转化进行脂质合成以及通过组织切片孵育来检测钠钾泵的活性,以此作为组织活力的参数。在灌注前后,通过血管造影和微球技术研究血液循环情况。灌注6天后发现,与肾皮质相比,肿瘤组织的活力较低。

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