Appelboom T, Famaey J P, Görtz R, Wybran J
Agents Actions. 1981 Dec;11(6-7):604-5. doi: 10.1007/BF01978759.
The leukocyte adherence inhibition test can serve as an in vitro model to investigate the cellular cooperation between T cells, monocytes and polymorphonuclear cells (PMN) but also the mechanism of cell adherence. Therefore, the effect of levamisole on the production of PMN activating factors by mononuclear cells and on cell adherence was studied with leukocytes from polyarthritic patients. Levamisole at concentrations ranging from 10(-9) M to 10(-4) M did not seem to affect the production of activating factors. These results differentiate levamisole from anti-inflammatory drugs which are potent inhibitors. On the other hand, levamisole increased markedly the adherence of leucocytes, mainly mononuclear cells, obtained from polyarthritic patients, or normal cells preincubated in a polyarthritic serum. This could be related to a direct effect of levamisole on the leukocyte membrane.
白细胞黏附抑制试验可作为一种体外模型，用于研究T细胞、单核细胞和多形核细胞（PMN）之间的细胞协作以及细胞黏附机制。因此，我们使用多关节炎患者的白细胞，研究了左旋咪唑对单核细胞产生PMN激活因子以及对细胞黏附的影响。浓度范围为10^(-9) M至10^(-4) M的左旋咪唑似乎并不影响激活因子的产生。这些结果将左旋咪唑与强效抑制剂类抗炎药区分开来。另一方面，左旋咪唑显著增加了从多关节炎患者获得的白细胞（主要是单核细胞）或在多关节炎血清中预孵育的正常细胞的黏附。这可能与左旋咪唑对白细胞膜的直接作用有关。
