Greenstein R A, O'Brien C P, McLellan A T, Woody G E, Grabowski J, Long M, Coyle-Perkins G, Vittor A
Am J Drug Alcohol Abuse. 1981;8(3):291-300. doi: 10.3109/00952998109009554.
The narcotic antagonist, naltrexone, was studied in 242 patients during a 6-year period. Although a large number of subjects discontinued naltrexone abruptly, treatment was related to a significant decrease in opiate and nonopiate drug use. Methods for improving retention during induction and maintenance are discussed and posttreatment outcome results are presented. The authors conclude that naltrexone may be a useful short-term treatment option for opiate dependence.
在6年期间，对242名患者进行了麻醉拮抗剂纳曲酮的研究。尽管大量受试者突然停止使用纳曲酮，但治疗与阿片类药物和非阿片类药物使用的显著减少有关。讨论了在诱导和维持治疗期间提高留存率的方法，并给出了治疗后的结果。作者得出结论，纳曲酮可能是阿片类药物依赖的一种有用的短期治疗选择。
