Gold M S, Dackis C A, Washton A M
Adv Alcohol Subst Abuse. 1984 Spring;3(3):19-39. doi: 10.1300/J251v03n03_03.
The efficacy of clonidine in the management of opiate withdrawal states has improved and refined the medical approach to this condition. In addition, the use of clonidine for opiate detoxification paves the way for naltrexone maintenance. Naltrexone, by providing chronic opiate receptor blockade, prevents opiate intoxication and subsequent readdiction in recovered addicts. The sequential use of clonidine and naltrexone, in conjunction with drug rehabilitation, appears to represent a viable and effective treatment for opiate addiction in motivated patients. The development of clonidine and naltrexone as treatment agents for opiate addiction also demonstrates that neurobiological advances can be translated into new and effective clinical approaches. This paper summarizes some of our experiences with the clonidine/naltrexone approach in motivated opiate addicts.
可乐定在阿片类药物戒断状态管理中的疗效改善并完善了针对该病症的医学治疗方法。此外，使用可乐定进行阿片类药物脱毒为纳曲酮维持治疗铺平了道路。纳曲酮通过提供慢性阿片受体阻断作用，可防止康复成瘾者出现阿片类药物中毒及随后的再次成瘾。在药物康复治疗的同时序贯使用可乐定和纳曲酮，似乎是一种针对有治疗意愿的阿片类药物成瘾患者的可行且有效的治疗方法。将可乐定和纳曲酮开发为阿片类药物成瘾的治疗药物也表明，神经生物学进展能够转化为新的有效临床方法。本文总结了我们在有治疗意愿的阿片类药物成瘾者中使用可乐定/纳曲酮方法的一些经验。
