霍乱毒素、破伤风毒素及其组分的疏水性
The hydrophobicities of cholera toxin, tetanus toxin and their components.
作者信息
Ward W H, Britton P, van Heyningen S
出版信息
Biochem J. 1981 Nov 1;199(2):457-60. doi: 10.1042/bj1990457.
Abstract
- Charge-shift electrophoresis showed that cholera toxin and its subunits have no hydrophobic surfaces. 2. Amino-acid composition and sequence data suggested that the proteins have no masked hydrophobic regions. 3. The A subunit of cholera toxin may interact with polar molecules in the membrane to exert its effect inside the cell. 4. The only hydrophobic part of tetanus toxin was the H-chain.
摘要
- 电荷转移电泳显示霍乱毒素及其亚基没有疏水表面。2. 氨基酸组成和序列数据表明这些蛋白质没有隐藏的疏水区域。3. 霍乱毒素的A亚基可能与膜中的极性分子相互作用，从而在细胞内发挥其作用。4. 破伤风毒素唯一的疏水部分是H链。
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