芳香胺对仓鼠胚胎细胞的转化作用。
Transformation of hamster embryo cells by aromatic amines.
作者信息
Pienta R J, Kawalek J C
出版信息
Natl Cancer Inst Monogr. 1981 Dec(58):243-51.
PMID:7341981
Abstract
a mammalian cell transformation system that required cryopreserved primary cultures of Syrian golden hamster embryo cells was used in the evaluation of the carcinogenic potential of 46 structurally related aromatic amines. The results generally correlated with those obtained with animal bioassay systems. However, several carcinogenic compounds required the addition of an exogenous metabolic activation system provided by hamster liver S9 homogenate enzymes or cultured hepatocytes to transform the hamster embryo cells.
摘要
一种需要使用冷冻保存的叙利亚金仓鼠胚胎细胞原代培养物的哺乳动物细胞转化系统，被用于评估46种结构相关的芳香胺的致癌潜力。结果总体上与动物生物测定系统所获得的结果相关。然而，几种致癌化合物需要添加由仓鼠肝脏S9匀浆酶或培养的肝细胞提供的外源性代谢活化系统，才能转化仓鼠胚胎细胞。
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