Kasemsuth R, Panut-ampon P, Sanghirun C
Southeast Asian J Trop Med Public Health. 1981 Sep;12(3):410-2.
A diagnostic method for gnathostomiasis by radioimmunoassay was carried out. Antibody activity produced in cat serum against Gnathostoma antigen was measured by using solid phase method and 125I-labelled anti cat IgG antibody. The result showed that the antibody activity in cats infected with Gnathostoma spinigerum was significantly higher than those of the control group and the Toxocara infected cats even at the dilution of 1:10,000, except in the Opisthorchis infected group at the dilution higher than 1:400. The results in the present study seem to be promising for the diagnosis of gnathostomiasis. Cross reaction with other parasitic infections and the development for the higher specificity by this method is in progress.
开展了用放射免疫测定法诊断颚口线虫病的方法。采用固相法和125I标记的抗猫IgG抗体，测定猫血清中针对颚口线虫抗原产生的抗体活性。结果显示，即使在1:10,000稀释度下，感染棘颚口线虫的猫的抗体活性也显著高于对照组和感染弓首蛔虫的猫，但在高于1:400稀释度的华支睾吸虫感染组中除外。本研究结果对于颚口线虫病的诊断似乎很有前景。目前正在研究该方法与其他寄生虫感染的交叉反应以及提高其特异性。
