Hirschl A, Stanek G, Rotter M
Zentralbl Bakteriol Mikrobiol Hyg B. 1981 Dec;174(6):523-9.
Commercially available gargles containing (hexetidin 0.1%, dequaliniumchloride 0.01%, benzydamin 0.15%) or not containing (OdolTM 0.5%) antibacterials as well as hydrogen-peroxide (3% ml/ml) and aqua dest. as a control tested for their antibacterial efficacy in vivo by applying them for 30 s. Standardized mouth- and throat-washings of 15 volunteers were examined for their aerobic viable counts before as well as 5 and 60 min after gargling. The 5-minutes values (tab. 1) indicated only hexetidin to reduce the oro-pharyngeal flora significantly though not very profoundly by 0.95 orders of magnitude. Usage of the other gargles caused only log reductions of 0.16 to 0.39, aqua dest. such of 0.23. Sixty minutes after treatment (tab 2.) there was still a small but significant reduction of 0.61 log units demonstrable with hexetidin and the viable counts after treatment with hydrogen-peroxide were 0.31 log units below the baseline. The log reductions as assessed with the other gargles ranged 0.0 to 0.18. It is concluded that the favourable therapeutic effects observed clinically with many "antiseptic" gargles with infections of the upper respiratory tract are not based on the antibacterial efficacy of such preparations.
含有（洗必泰0.1%、地喹氯铵0.01%、苄达明0.15%）或不含（奥多液TM 0.5%）抗菌剂以及3%（毫升/毫升）过氧化氢和去离子水的市售漱口水作为对照，通过应用30秒来测试其体内抗菌效果。对15名志愿者的标准化口腔和咽喉冲洗液在漱口前以及漱口后5分钟和60分钟进行需氧活菌计数检查。5分钟时的值（表1）显示只有洗必泰能显著降低口咽菌群数量，尽管降低幅度不是很大，为0.95个数量级。使用其他漱口水仅使对数减少0.16至0.39，去离子水使对数减少0.23。治疗60分钟后（表2），洗必泰仍能使活菌数显著减少0.61个对数单位，过氧化氢治疗后的活菌数比基线低0.31个对数单位。用其他漱口水评估的对数减少范围为0.0至0.18。得出的结论是，临床上观察到的许多“抗菌”漱口水对上呼吸道感染具有良好治疗效果并非基于此类制剂的抗菌功效。
