Kramer A, Höppe H, Krull B, Pitten F A, Rosenau S
Institut für Hygiene und Umweltmedizin, Ernst-Moritz-Arndt-Universität Greifswald.
Zentralbl Hyg Umweltmed. 1998 Feb;200(5-6):443-56.
The efficacy of common antiseptic mouth rinses was evaluated in a study with healthy volunteers. Octenisept and Cetylpyridiniumchlorid had a significant stronger impact on the microbial burden of the oral cavity than Chlorhexidin (Corsodyl) immediately and 10 min after the application. Dobendan (contains Cetylpyridiniumchlorid) showed a better antimicrobial effect than Corsodyl immediately after application, after 10 min an increasing loss of efficacy was noted. The antiseptic efficacy of hexetidin-based Gurfix was very similar to the efficacy observed with Corsodyl from the start of the antiseptic treatment until 1 h later. Acriflavine-solution (0.2% m/v) was significantly less efficient after 10, 30 and 60 min compared to Corsodyl. The antimicrobial impact of Fluomint-Lysoform was very similar to the effect of rinsing with dest. sterile water. A subjective assessment of taste and smell of the mouth rinse solutions concludes the evaluation. Further methodological aspects for a common test guideline for antiseptic mouth rinse solutions are discussed.
在一项针对健康志愿者的研究中评估了常见抗菌漱口水的功效。奥替尼啶和西吡氯铵在使用后即刻和10分钟时，对口腔微生物负荷的影响比氯己定（洗必泰）显著更强。多本丹（含西吡氯铵）在使用后即刻显示出比洗必泰更好的抗菌效果，但在10分钟后观察到功效逐渐丧失。从抗菌治疗开始直至1小时后，基于己脒定的固齿灵的抗菌功效与洗必泰观察到的功效非常相似。与洗必泰相比，吖啶黄溶液（0.2% m/v）在10、30和60分钟后效率显著较低。氟薄荷-溶菌酶的抗菌作用与用蒸馏水冲洗的效果非常相似。对漱口水溶液的味道和气味进行主观评估以完成评估。讨论了抗菌漱口水溶液通用测试指南的进一步方法学方面。
