Sundbeck A, Alpsten M, Appelgren L, Karlsson L, Månsson L G, Peterson H I
Anticancer Res. 1981;1(3):141-8.
The influence on the intratumour blood flow distribution in a transplantable rat sarcoma by a potent antifibrinolytic drug, tranexamic acid, administered intraperitoneally for 3 or 10 days was studied by the intratumour distribution of intravenously injected 86Rb. A local Xenon clearance technique was used to study the direct effect of tranexamic acid on local tumour blood flow. local tumour blood flow and the intratumour blood flow distribution after administration of tranexamic acid for 3 days were unchanged compared to controls. Prolonged administration of tranexamic acid changed the intratumour blood flow distribution significantly towards low flow values. This might be one mechanism behind the inhibiting effect of tranexamic acid in tumour growth rate, previously observed in both experimental and clinical studies.
通过静脉注射⁸⁶Rb在肿瘤内的分布，研究了腹腔注射有效抗纤维蛋白溶解药物氨甲环酸3天或10天对可移植大鼠肉瘤肿瘤内血流分布的影响。采用局部氙清除技术研究氨甲环酸对局部肿瘤血流的直接影响。与对照组相比，氨甲环酸给药3天后局部肿瘤血流和肿瘤内血流分布未发生变化。长期给予氨甲环酸可使肿瘤内血流分布显著向低流量值改变。这可能是氨甲环酸抑制肿瘤生长率的作用机制之一，此前在实验和临床研究中均有观察到。
