[马里乙型肝炎慢性携带者状态的流行病学和病理结果]

[Epidemiology and pathologic results of chronic carriers state of hepatitis B in Mali].

作者信息

Maupas P, Chiron J P, Goudeau A, Coursaget P, Perrin J, Barin F, Yvonnet B, Dubois F, Duflo B, Duflo-Moreau B, Sidibe S, Diallo A N

出版信息

Bull Soc Pathol Exot Filiales. 1981 Nov-Dec;74(6):722-32.

PMID:7343138

Abstract

The HB antigen of the hepatitis B (HB) virus, studied by counter immunoelectrophoresis shows a prevalence of 8.7% in 1,860 rural Malians and 11.3% in 764 blood donors from Bamako. Amongst 1,350 hospitalised patients, no correlation could be established between the HBs antigen chronic carriers state and other infectious diseases, malnutrition or genetic deficiencies. On the other hand, the prevalence of HBs antigen is particularly high in hepatic infections: acute and chronic hepatitis (53.5%), cirrhosis (31.5%) and hepatomas (25.3%). The study of the prevalence of hepatitis B by radioimmunoassay of the HBV seric markers was carried out in: --176 "healthy" town dwellers of which 97.2% were carriers of at least one marker--HBs Ag: 16.5%; anti-HBc alone: 34.1%; anti-HBs: 46.6%--. --30 subjects with cirrhosis--HBs Ag: 66.7%; anti-HBc alone: 10.0%; anti-HBs: 23.3%--. --42 subjects with PHC--HBs Ag: 47.6%; anti-HBc alone: 23.8%; anti-HBs: 28.6%--. The difference in HBs Ag carrier state between patients (cirrhosis and PHC) and controls, cross-matched for sex and age, is highly significative--p = 0,0001--.

摘要

通过对流免疫电泳研究的乙肝（HB）病毒的HB抗原，在1860名马里农村人中的流行率为8.7%，在764名来自巴马科的献血者中的流行率为11.3%。在1350名住院患者中，HBs抗原慢性携带者状态与其他传染病、营养不良或遗传缺陷之间未发现相关性。另一方面，HBs抗原在肝脏感染中流行率特别高：急性和慢性肝炎（53.5%）、肝硬化（31.5%）和肝癌（25.3%）。通过对HBV血清标志物进行放射免疫测定来研究乙肝的流行率，研究对象包括：——176名“健康”城镇居民，其中97.2%至少携带一种标志物——HBs Ag：16.5%；单独抗-HBc：34.1%；抗-HBs：46.6%。——30名肝硬化患者——HBs Ag：66.7%；单独抗-HBc：10.0%；抗-HBs：23.3%。——42名原发性肝癌患者——HBs Ag：47.6%；单独抗-HBc：23.8%；抗-HBs：28.6%。在按性别和年龄进行交叉匹配的患者（肝硬化和原发性肝癌患者）与对照组之间，HBs Ag携带者状态的差异具有高度显著性——p = 0.0001。