月经周期及口服避孕药对白人女性酒精药代动力学的影响。

Menstrual cycle and oral contraceptive effects on alcohol pharmacokinetics in caucasian females.

作者信息

Zeiner A R, Kegg P S

出版信息

Curr Alcohol. 1981;8:47-56.

Abstract

We investigated the relationship between oral contraceptives, day of menstrual cycle and alcohol pharmacokinetics in 20 Caucasian females. Peak blood alcohol concentration was higher and clearance rates were faster on Day 1 (when hormonal levels were low) than on Day 24. No pill subjects reached a higher BAC than did pill subjects on Day 24 but not on Day 1. Clearance rates of no pill subjects were faster on Day 24 than for pill subjects. Results suggest that female sex steroids, directly or indirectly, reduce peak BAC and slow clearance rates.

摘要

我们对20名高加索女性口服避孕药、月经周期天数与酒精药代动力学之间的关系进行了研究。与第24天相比，第1天（激素水平较低时）的血酒精浓度峰值更高，清除率更快。在第24天而非第1天，未服用避孕药的受试者没有达到比服用避孕药的受试者更高的血液酒精浓度（BAC）。未服用避孕药的受试者在第24天的清除率比服用避孕药的受试者更快。结果表明，女性甾体激素直接或间接降低了血酒精浓度峰值并减缓了清除率。