Johnson A L, van Tienhoven A
Poult Sci. 1981 Dec;60(12):2720-3. doi: 10.3382/ps.0602720.
The plasma metabolic clearance rate (MCR), production rate (PR), and half-life (T 1/2) of estradiol-17 beta (E2) were determined in 5 laying hens at a time 2 to 4 hr after oviposition of the second egg in the clutch. Pharmacokinetic parameters were calculated from data obtained after a single injection of 3H-E2. Results indicate that the disappearance of 3H-E2 from the plasma best fits a two compartment model. The MCR was calculated to be 77.3 +/- 14.2 (mean +/- SE) ml plasma/min/kg and the PR 6.36 +/- 1.46 ng/min. The T 1/2 for the distribution (or alpha) phase was 1.1 +/- .2 min and for the storage, metabolism, and excretory (or beta) phase was 27.5 +/- 6.5 min. We conclude that the MCR and T 1/2 alpha of E2 are similar to previously published values for progesterone (P4) but that the PR is substantially lower. This difference can account for the lower circulating basal levels of E2, compared to P4, in the laying hen.
在一窝蛋中第二个蛋产出后2至4小时，测定了5只产蛋母鸡中雌二醇 - 17β（E2）的血浆代谢清除率（MCR）、生成率（PR）和半衰期（T1/2）。药代动力学参数由单次注射3H - E2后获得的数据计算得出。结果表明，血浆中3H - E2的消失最符合二室模型。计算得出MCR为77.3±14.2（平均值±标准误）ml血浆/分钟/千克，PR为6.36±1.46 ng/分钟。分布（或α）相的T1/2为1.1±0.2分钟，储存、代谢和排泄（或β）相的T1/2为27.5±6.5分钟。我们得出结论，E2的MCR和T1/2α与先前发表的孕酮（P4）值相似，但PR显著更低。这种差异可以解释产蛋母鸡中与P4相比E2较低的循环基础水平。
