人类白细胞抗原（HLA）抗原与乙型肝炎病毒（HBV）感染：慢性携带者状态及一个大家族中的评估

HLA antigens and HBV infection: evaluation in the chronic carrier state and in a large family.

作者信息

Sampliner R E, Bias W B, Carney E, Hillis A, Hillis W D

出版信息

Tissue Antigens. 1981 Oct;18(4):247-51. doi: 10.1111/j.1399-0039.1981.tb01388.x.

DOI:10.1111/j.1399-0039.1981.tb01388.x

Abstract

HLA antigens were determined in 65 apparently well chronic carriers of HBsAg, in race-matched controls and in 42 members of a family with a high frequency of hepatitis B virus infection. The only apparent significant association in the chronic carriers was negative, i.e., no HLA-B7 specificities were found among whites. B7 may confer resistance for whites to chronic infection with hepatitis B. In the family neither active (HBsAg) nor prior (anti-HBs) hepatitis B infection was associated with HLA specificities. HLA antigens in this family failed to provide a clue to the genetics of hepatitis B infection.

摘要

对65名表面健康的乙肝表面抗原慢性携带者、种族匹配的对照组以及一个乙肝病毒感染高发家庭的42名成员进行了人类白细胞抗原（HLA）抗原检测。慢性携带者中唯一明显的显著关联为阴性，即白人中未发现HLA - B7特异性。B7可能赋予白人对乙肝慢性感染的抵抗力。在该家庭中，现患（乙肝表面抗原）或既往（乙肝表面抗体）乙肝感染均与HLA特异性无关。该家庭中的HLA抗原未能为乙肝感染的遗传学提供线索。