Heidel J R, Giddens W E, Boyce J T
Vet Pathol. 1981 Apr;18(Suppl 6):59-69. doi: 10.1177/0300985881018s0607.
Renal disease was found at necropsy in 27 of 60 catheterized baboons (Papio cynocephalus). Primary diagnoses were infarcts in eight baboons, septic embolic nephritis in four, and mesangioproliferative glomerulonephritis in 15. Infarcts and septic embolic nephritis are multifocal renal diseases; mesangioproliferative glomerulonephritis is diffuse, progressive and often accompanied by severe proteinuria, hypoalbuminemia (less than 3 g/dl), and generalized edema. Five of the 15 baboons with glomerulonephritis also developed uremia and died of renal failure. Ten baboons with glomerulonephritis were given microbiological examination during their clinical course. Bacteria were isolated from the peripheral blood of eight baboons and from the catheter itself in two. The organisms isolated (in decreasing order of frequency) were Herellea sp., Streptococcus sp., Klebsiella sp., Staphylococcus sp., and Providencia sp. Prospective immunofluorescence studies were done on frozen sections from six catheterized baboons with glomerulonephritis and two uncatheterized controls. There were granular deposits of IgG in all six, IgM in five, C3 in four, and IgA and C4 in two. In the controls, only trace amounts of IgM were seen in one animal. The amount of IgG deposited in th glomeruli correlated with the severity of the glomerulonephritis. Bacterial antigens were found by immunofluorescence in glomeruli of three of five baboons examined. Glomerulonephritis in these baboons seems to be immunologically mediated, and in origin, pathogenesis and morphologic expression resembles shunt nephritis in humans with infected indwelling shunts and catheters.
在60只接受导管插入术的狒狒（豚尾狒狒）中，有27只在尸检时发现患有肾脏疾病。主要诊断结果为：8只狒狒患有梗死，4只患有败血性栓塞性肾炎，15只患有系膜增生性肾小球肾炎。梗死和败血性栓塞性肾炎是多灶性肾脏疾病；系膜增生性肾小球肾炎是弥漫性、进行性的，常伴有严重蛋白尿、低白蛋白血症（低于3g/dl）和全身性水肿。15只患有肾小球肾炎的狒狒中有5只还发展为尿毒症并死于肾衰竭。10只患有肾小球肾炎的狒狒在其临床病程中接受了微生物学检查。从8只狒狒的外周血和2只狒狒的导管本身分离出了细菌。分离出的微生物（按频率递减顺序）为赫雷氏菌属、链球菌属、克雷伯菌属、葡萄球菌属和普罗威登斯菌属。对6只患有肾小球肾炎的导管插入术狒狒和2只未接受导管插入术的对照动物的冰冻切片进行了前瞻性免疫荧光研究。6只动物均有IgG颗粒沉积，5只有IgM沉积，4只有C3沉积，2只有IgA和C4沉积。在对照动物中，仅在1只动物中发现微量IgM。肾小球中IgG的沉积量与肾小球肾炎的严重程度相关。在接受检查的5只狒狒中，有3只的肾小球通过免疫荧光发现了细菌抗原。这些狒狒的肾小球肾炎似乎是免疫介导的，在起源、发病机制和形态学表现上类似于人类因留置分流管和导管感染而导致的分流性肾炎。
