Leary S L, Sheffield W D, Strandberg J D
Lab Anim Sci. 1981 Aug;31(4):416-20.
Baboons with long term, indwelling, intravascular catheters developed clinical signs of renal and hepatic impairment. These included proteinuria and hypoalbuminemia without edema, and albumin to globulin ratios were reversed. Serum IgM, IgG, rheumatoid factor, and liver enzyme concentrations were above normal. Immunofluorescent staining of renal glomerular capillary loops was positive for IgG, IgM, B1c, and C4. Major microscopic lesions were membranoproliferative glomerulonephritis, chronic active hepatitis, degenerative arthritis, and chronic sialoadenitis. Electron microscopy of renal glomeruli demonstrated dense deposits in a variety of locations, mesangial cell interpositioning, and foot process fusion. These alterations, found in conjunction with the isolation of Staphylococcus aureus from the blood of affected baboons as well as the intravascular catheters, suggested that chronic bacterial infection was important in the pathogenesis of this disease.
长期留置血管内导管的狒狒出现了肾和肝损伤的临床症状。这些症状包括无水肿的蛋白尿和低白蛋白血症，且白蛋白与球蛋白比值倒置。血清IgM、IgG、类风湿因子和肝酶浓度高于正常水平。肾肾小球毛细血管袢的免疫荧光染色显示IgG、IgM、B1c和C4呈阳性。主要的微观病变为膜增生性肾小球肾炎、慢性活动性肝炎、退行性关节炎和慢性涎腺炎。肾小球的电子显微镜检查显示在多个部位有致密沉积物、系膜细胞插入和足突融合。这些改变，再加上从受影响狒狒的血液以及血管内导管中分离出金黄色葡萄球菌，表明慢性细菌感染在该疾病的发病机制中起重要作用。
