Giddens W E, Boyce J T, Blakley G A, Morton W R
Vet Pathol. 1981 Apr;18(Suppl 6):70-81. doi: 10.1177/0300985881018s0608.
Spontaneous renal disease in the pigtailed macaque was evaluated in a prospective study of 20 apparently healthy monkeys that were killed and a retrospective study of 674 monkeys that died of spontaneous disease. Many apparently normal pigtailed macaques have a mesangioproliferative glomerulonephritis of slight to moderate severity. Deposition of immunoglobulin, particularly IgM, was common in renal glomeruli and did not seem to correlate with renal disease. Glomerulonephritis was found in 14% of the adult monkeys that died of spontaneous disease; in 4.2% it was severe enough to have caused renal failure. Tubular nephrosis was the most common renal lesion (22.6% of adults) and was usually a nephrotoxicity resulting from treatment of diarrhea with nephrotoxic antibiotics. Other lesions found were incidental or were secondary to disease processes in other organs. Pigtailed macaques that have been in our colony at least six months have a higher incidence of renal disease than is reported elsewhere in Old World monkeys.
在一项对20只被处死的看似健康的猴子的前瞻性研究以及对674只死于自发性疾病的猴子的回顾性研究中，对豚尾猕猴的自发性肾脏疾病进行了评估。许多看似正常的豚尾猕猴患有轻度至中度严重程度的系膜增生性肾小球肾炎。免疫球蛋白，尤其是IgM，在肾小球中的沉积很常见，且似乎与肾脏疾病无关。在死于自发性疾病的成年猴子中，14%发现有肾小球肾炎；其中4.2%严重到足以导致肾衰竭。肾小管肾病是最常见的肾脏病变（占成年猴子的22.6%），通常是由于用肾毒性抗生素治疗腹泻导致的肾毒性。发现的其他病变是偶然的或继发于其他器官的疾病过程。在我们的猴群中饲养至少六个月的豚尾猕猴比其他旧世界猴子中报道的肾脏疾病发病率更高。
