Landsverk T
Acta Vet Scand. 1981;22(3-4):459-71. doi: 10.1186/BF03548671.
Twelve 2–5-week-old calves affected with a spontaneous intestinal disorder were examined; 8 had diarrhea and 4 were convalescents. In all the affected calves the “pseudovilli” (syn. domes or lymphoid villi) over Peyer’s patches seemed atrophic and appeared enclosed within the mucosa, owing to fusion of ordinary villi with “pseudovilli”. Morphometric examination showed a decrease of lymphoid follicle length in the affected calves as compared with controls (P < 0.01). Convalescents showed longer follicles than diarrheic calves (P<0.05). Often cytoplasmic acid phosphatase of the follicle-associated epithelium (FAE) in affected calves did not show the marked basal-apical decrease along “pseudovillus”, typical of the controls. Scanning electron microscopy revealed sparse development of concentric folds in the luminal plasma membrane of the enclosed FAE, contrasting with their abundance in the normal FAE. Transmission electron microscopy showed that the “pseudovilli” had increased numbers of ordinary villous epithelial cells. Affinity of chlamydia for FAE was shown. It is suggested that the sparse occurrence of surface folds in the FAE and the change in acid phosphatase distribution indicate diminished endocytosis of antigenic material, probably resulting from the enclosure of “pseudovilli”. The atrophy of lymphoid follicles may be another expression of the probable decreased contact with the intestinal contents.
对12头患有自发性肠道疾病的2 - 5周龄犊牛进行了检查；其中8头发泄，4头处于恢复期。在所有患病犊牛中，派伊尔氏淋巴集结上的“假绒毛”（同义词：穹顶或淋巴绒毛）似乎萎缩，并因普通绒毛与“假绒毛”融合而被包裹在黏膜内。形态计量学检查显示，与对照组相比，患病犊牛的淋巴滤泡长度缩短（P<0.01）。恢复期犊牛的滤泡比腹泻犊牛的长（P<0.05）。患病犊牛中，滤泡相关上皮（FAE）的胞质酸性磷酸酶通常不像对照组那样沿“假绒毛”呈现从基底到顶端的显著减少。扫描电子显微镜显示，被包裹的FAE腔面膜上同心褶皱发育稀疏，这与正常FAE中褶皱丰富形成对比。透射电子显微镜显示，“假绒毛”中有更多数量的普通绒毛上皮细胞。研究显示衣原体对FAE具有亲和性。有人提出，FAE表面褶皱稀少以及酸性磷酸酶分布变化表明抗原物质的内吞作用减弱，这可能是“假绒毛”被包裹所致。淋巴滤泡萎缩可能是与肠内容物接触可能减少的另一种表现。
