Burgat-Sacaze V, Delatour P, Rico A
Ann Rech Vet. 1981;12(3):277-89.
Basic considerations dealing with the biological significance of drug residues and safety evaluation are studied. The specific problem of covalently bound residues is considered from three different points of view. (1) Analytical characteristics clearly distinguish between soluble residues, which deplete relatively fast, and bound material which is slowly eliminated from edible tissues of target animals. (2) These two residual fractions have not the same bioavailability. (3) Finally, toxicity assessment of bound residues is considered.
研究了与药物残留的生物学意义和安全性评估相关的基本考量因素。从三个不同角度考虑了共价结合残留的具体问题。（1）分析特征清楚地区分了相对快速消耗的可溶性残留和从目标动物可食用组织中缓慢消除的结合物质。（2）这两种残留部分具有不同的生物利用度。（3）最后，考虑了结合残留的毒性评估。
