DL-烯丙基甘氨酸对大鼠杏仁核点燃的影响（作者译）
[Effect of DL-allyglycine on amygdala kindling in the rat (author's transl)].
作者信息
Rondouin G, Baldy-Moulinier M, Passouant P
出版信息
Rev Electroencephalogr Neurophysiol Clin. 1981 Dec;11(3-4):329-34. doi: 10.1016/s0370-4475(81)80069-x.
PMID:7345490
Abstract
The effect of decreased cerebral GABA levels on the development of amygdaloid kindling in rats was investigated. DL-Allylglycine, an inhibitor of glutamic acid decarboxylase (GAD), administered for 2 or 9 days (100 mg/kg and 50 mg/kg respectively) was found to accelerate the kindling process. The results are discussed according to a possible role of GABA mechanisms in the kindling phenomenon.
摘要
研究了大鼠脑内γ-氨基丁酸（GABA）水平降低对杏仁核点燃发展的影响。发现给予谷氨酸脱羧酶（GAD）抑制剂DL-烯丙基甘氨酸2天或9天（分别为100mg/kg和50mg/kg）可加速点燃过程。根据GABA机制在点燃现象中可能发挥的作用对结果进行了讨论。
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