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[吸入镉在大鼠肺部的清除动力学及其在肝脏和肾脏中的蓄积]

[Kinetics of the pulmonary clearance of inhaled cadmium and its accumulation in rat liver and kidneys].

作者信息

Boisset M, Girard F, Godin J, Boudène C

出版信息

C R Acad Hebd Seances Acad Sci D. 1978 Jul 3;187(1):61-4.

PMID:100238
Abstract

Pulmonary clearance rate of cadmium (Cd), inhaled in the form of an aerosol of Cd acetate, is very slow (half-life 53 days). However, results demonstrate that an important part of Cd cleared from the lung is recovered in liver and kidney. Liver binds this metal rapidly but to a limited extent, whereas renal accumulation is slow but continuous throughout the three months following exposure.

摘要

以醋酸镉气溶胶形式吸入的镉(Cd)的肺清除率非常缓慢(半衰期为53天)。然而,结果表明,从肺部清除的镉的一大部分在肝脏和肾脏中被重新发现。肝脏迅速结合这种金属,但程度有限,而肾脏中的积累则很缓慢,但在接触后的三个月内持续进行。

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1
[Kinetics of the pulmonary clearance of inhaled cadmium and its accumulation in rat liver and kidneys].[吸入镉在大鼠肺部的清除动力学及其在肝脏和肾脏中的蓄积]
C R Acad Hebd Seances Acad Sci D. 1978 Jul 3;187(1):61-4.
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Lung deposition and clearance of cadmium in rats exposed by inhalation or by intratracheal instillation.
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Cellular and biochemical response of the rat lung to repeated inhalation of cadmium.大鼠肺对反复吸入镉的细胞和生化反应。
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Cadmium accumulation and metallothionein concentrations after 4-week dietary exposure to cadmium chloride or cadmium-metallothionein in rats.大鼠经4周饮食暴露于氯化镉或镉-金属硫蛋白后的镉蓄积及金属硫蛋白浓度
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Importance of species differences in experimental pulmonary carcinogenicity of inhaled cadmium for extrapolation to humans.吸入镉的实验性肺致癌性中物种差异对于外推至人类的重要性。
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[Effects of zinc-aerosols on the inhalation toxicity of cadmium (author's transl)].[锌气雾剂对镉吸入毒性的影响(作者译)]
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