[吸入镉在大鼠肺部的清除动力学及其在肝脏和肾脏中的蓄积]

[Kinetics of the pulmonary clearance of inhaled cadmium and its accumulation in rat liver and kidneys].

作者信息

Boisset M, Girard F, Godin J, Boudène C

出版信息

C R Acad Hebd Seances Acad Sci D. 1978 Jul 3;187(1):61-4.

Abstract

Pulmonary clearance rate of cadmium (Cd), inhaled in the form of an aerosol of Cd acetate, is very slow (half-life 53 days). However, results demonstrate that an important part of Cd cleared from the lung is recovered in liver and kidney. Liver binds this metal rapidly but to a limited extent, whereas renal accumulation is slow but continuous throughout the three months following exposure.

摘要

以醋酸镉气溶胶形式吸入的镉（Cd）的肺清除率非常缓慢（半衰期为53天）。然而，结果表明，从肺部清除的镉的一大部分在肝脏和肾脏中被重新发现。肝脏迅速结合这种金属，但程度有限，而肾脏中的积累则很缓慢，但在接触后的三个月内持续进行。