Tsikalova R, Nikolova M, Nikolov R
Acta Physiol Pharmacol Bulg. 1981;7(4):43-8.
In view of the interesting problem of the correlation between the functional cerebral activity and cerebral blood circulation, as well as the controversy in the literature concerning the effects of tranquilizers on cerebral blood circulation, the effects of the daily tranquilizer Lonetyl on the spontaneous cerebral bioelectrical activity and cerebral haemodynamics have been studied. According to rheoencephalographic data, Lonetyl is found to reduce cerebral vascular tone, which is manifested by decreased values of the relative share and the dicrotic index, the maximum effect being observed between the 15th and 30th min. The changes in the EEG consist in significant increase of the alpha- and theta-activity, with maximum effect on the 15th min, increased mean frequency and decreased mean amplitude. Synchronization of the cerebral bioelectrical activity is observed after the 30th min.
鉴于大脑功能活动与脑血液循环之间相关性这一有趣问题，以及文献中关于镇静剂对脑血液循环影响的争议，已对每日服用的镇静剂洛内蒂尔（Lonetyl）对自发性脑生物电活动和脑血流动力学的影响进行了研究。根据脑血流图数据，发现洛内蒂尔可降低脑血管张力，表现为相对份额值和重搏波指数降低，在第15至30分钟时观察到最大效果。脑电图的变化包括α波和θ波活动显著增加，在第15分钟时效果最大，平均频率增加，平均振幅降低。在第30分钟后观察到脑生物电活动同步。
