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卡马西平治疗精神和行为障碍:一项初步研究。

Carbamazepine in the treatment of psychotic and behavioral disorders. A pilot study.

作者信息

DE Vogelaer J

出版信息

Acta Psychiatr Belg. 1981 Nov-Dec;81(6):532-41.

PMID:7345908
Abstract

Symptoms of (mostly psychotic) agitation and symptoms of disrupted behavior, loss of impulse control (such as aggressiveness, impulsivity, perversity, suicidal attempts, orality, pseudomania which means mania subjectively experienced as unpleasant mania, mania not responding to lithium treatment) and EPS (very pronounced in group A, less in the other subgroups) in patients with a premorbid active-ambivalent personality pattern, in the absence of clinical and EEG signs of epilepsy, constitute an indication for the use of carbamazepine. This drugs allows a reduction, sometimes marked, of high doses of neuroleptics, as well as of many doubtful indications for lithium, characterised by our selection criteria.

摘要

对于病前具有主动-矛盾型人格模式的患者,在无癫痫的临床及脑电图体征情况下,出现(大多为精神病性的)激越症状、行为紊乱症状、冲动控制丧失(如攻击性、冲动性、乖僻行为、自杀企图、口欲期表现、主观体验为不愉快躁狂的假性躁狂、对锂盐治疗无反应的躁狂)以及锥体外系反应(在A组非常明显,在其他亚组中较轻),构成使用卡马西平的指征。这种药物有时能显著减少高剂量抗精神病药物的用量,以及许多不符合我们选择标准的锂盐治疗的可疑指征。

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