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长期职业性铅暴露、慢性肾病与肾癌:一例报告

Long-term occupational lead exposure, chronic nephropathy, and renal cancer: a case report.

作者信息

Lilis R

出版信息

Am J Ind Med. 1981;2(3):293-7. doi: 10.1002/ajim.4700020309.

DOI:10.1002/ajim.4700020309
PMID:7345929
Abstract

The case of a 61-year-old male with repeated episodes of overt clinical lead poisoning and courses of chelation therapy during his 34 years of employment in a secondary lead smelter is presented. Renal function impairment with elevated serum creatinine and blood urea nitrogen and with markedly reduced glomerular filtration rate was detected several years before the discovery of a clear cell adenocarcinoma of the right kidney. After successful surgical removal of the tumor, the patient's renal function continued its previous trend of slow deterioration.

摘要

本文介绍了一名61岁男性的病例,该患者在一家二级铅冶炼厂工作34年期间,多次出现明显的临床铅中毒发作并接受螯合治疗。在发现右肾透明细胞腺癌的数年前,就检测到其肾功能受损,血清肌酐和血尿素氮升高,肾小球滤过率显著降低。成功手术切除肿瘤后,患者的肾功能继续保持此前缓慢恶化的趋势。

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Long-term occupational lead exposure, chronic nephropathy, and renal cancer: a case report.长期职业性铅暴露、慢性肾病与肾癌:一例报告
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引用本文的文献

1
Mortality of lead smelter workers: A follow-up study with exposure assessment.铅冶炼工人的死亡率:一项伴有暴露评估的随访研究。
Am J Ind Med. 2016 Nov;59(11):979-986. doi: 10.1002/ajim.22618. Epub 2016 Jun 28.
2
Molecular and ionic mimicry and the transport of toxic metals.分子和离子模拟以及有毒金属的转运
Toxicol Appl Pharmacol. 2005 May 1;204(3):274-308. doi: 10.1016/j.taap.2004.09.007.
3
Mechanisms of kidney cell injury from metals.金属导致肾细胞损伤的机制。
Environ Health Perspect. 1993 Apr;100:57-63. doi: 10.1289/ehp.9310057.
4
Lead toxicity: current concerns.铅中毒:当前关注的问题。
Environ Health Perspect. 1993 Apr;100:177-87. doi: 10.1289/ehp.93100177.
5
Role of lead-binding proteins in renal cancer.铅结合蛋白在肾癌中的作用。
Environ Health Perspect. 1994 Sep;102 Suppl 3(Suppl 3):115-6. doi: 10.1289/ehp.94102s3115.
6
Cancer and occupational exposure to inorganic lead compounds: a meta-analysis of published data.癌症与职业性接触无机铅化合物:已发表数据的荟萃分析。
Occup Environ Med. 1995 Feb;52(2):73-81. doi: 10.1136/oem.52.2.73.
7
Mortality and cancer incidence among secondary lead smelter workers.二次铅冶炼厂工人的死亡率和癌症发病率。
Occup Environ Med. 1995 Oct;52(10):667-72. doi: 10.1136/oem.52.10.667.
8
Lead and hypertension in a mortality study of lead smelter workers.铅冶炼工人死亡率研究中的铅与高血压
Environ Health Perspect. 1988 Jun;78:65-6. doi: 10.1289/ehp.887865.
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Deaths from chronic renal disease in U.S. battery and lead production workers.美国电池和铅生产工人的慢性肾病死亡情况。
Environ Health Perspect. 1988 Jun;78:61-3. doi: 10.1289/ehp.887861.