Reznik G, Reznik-Schüller H M, Hayden D W, Russfield A, Murthy A S
Anticancer Res. 1981;1(5):279-86.
p-Cresidine was administered in the feed at either of two concentrations (0.5 and 1.0 percent) to groups of 50 male and 50 female F344 rats for 104 weeks. Fifty animals of each sex were placed on test as controls and fed only the basic laboratory diet. All animals were observed for up to 2 weeks after discontinuation of treatment. In treated rats of both sexes, statistically significant numbers of adenomas, adenocarcinomas and squamous cell carcinomas were diagnosed in the nasal cavity. Most of the neoplasms were seen in the high dose male and female rats. 22 male rats (49%) showed poorly differentiated adenocarcinomas infiltrating the skull and brain. Only two male rats (4%) had a squamous cell carcinoma, whereas 8 female rats (17%) had squamous cell carcinomas and 14 female rats (30%) were diagnosed as having adenocarcinomas of the nasal cavity. In the 4 neoplasms studied ultrastructurally, features characteristic of adenocarcinomas were identified. Cells were arranged around central lumina lined with microvilli. The luminal edges of cells were linked together by junctional complexes. Cytoplasmic differentiation was generally poor, with ribosomes and polyribosomes being the predominant organelles. Neurogenic features were rare and difficult to identify due to unsatisfactory fixation. In one of the tumors, areas of squamous differentiation were found. The cells constituting such areas contained prominent bundles of tonofilaments which are characteristic of early squamous metaplasia.
将对甲酚idine以两种浓度（0.5%和1.0%）之一添加到饲料中，分别喂给50只雄性和50只雌性F344大鼠，持续104周。每组50只各性别的动物作为对照，只喂基础实验室饲料。在停止治疗后，对所有动物观察长达2周。在接受治疗的两性大鼠中，鼻腔内诊断出数量具有统计学意义的腺瘤、腺癌和鳞状细胞癌。大多数肿瘤见于高剂量组的雄性和雌性大鼠。22只雄性大鼠（49%）出现低分化腺癌浸润颅骨和脑。只有两只雄性大鼠（4%）患有鳞状细胞癌，而8只雌性大鼠（17%）患有鳞状细胞癌，14只雌性大鼠（30%）被诊断为鼻腔腺癌。在超微结构研究的4个肿瘤中，确定了腺癌的特征性表现。细胞围绕内衬微绒毛的中央管腔排列。细胞的管腔边缘通过连接复合体连接在一起。细胞质分化通常较差，核糖体和多核糖体是主要细胞器。神经源性特征罕见，由于固定不佳难以识别。在其中一个肿瘤中，发现了鳞状分化区域。构成这些区域的细胞含有明显的张力丝束，这是早期鳞状化生的特征。
