Grasso P
Nutr Cancer. 1981;3(2):103-8. doi: 10.1080/01635588109513709.
There is no clear indication that malnutrition, per se, is a principal cause of cancer in man, but the prevalence of liver cancer in areas where malnutrition exists supports this hypothesis. Liver damage and liver cancer have been induced in laboratory rats by diets consisting of peanut meal and proteins deficient in some essential amino acids. However, liver damage, but not cancer, was produced when the diets contained no peanut meal but consisted of a mixture of amino acids deficient in methionine and cysteine, so that it is possible that aflatoxin, a contaminant of peanut meal, may have been responsible for the malignancies seen in the earlier experiments. Liver cancer developes in a high proportion of mice allowed to feed ad libitum or given a diet containing a high proportion of fat (groundnut oil) or protein (casein). Dietary restriction reduced the incidences of this cancer. This findings lends some support to current thinking that diet may be a factor in the development of cancer in man.
没有明确迹象表明营养不良本身是人类癌症的主要病因，但营养不良地区肝癌的高发率支持了这一假说。用由花生粕和某些必需氨基酸缺乏的蛋白质组成的饲料，在实验大鼠中诱发了肝损伤和肝癌。然而，当饲料不含花生粕，而是由蛋氨酸和半胱氨酸缺乏的氨基酸混合物组成时，只产生了肝损伤，而非癌症，因此花生粕中的污染物黄曲霉毒素可能是早期实验中所见恶性肿瘤的病因。在随意进食或食用含高比例脂肪（花生油）或蛋白质（酪蛋白）饲料的小鼠中，很大比例会发生肝癌。饮食限制降低了这种癌症的发病率。这一发现为目前认为饮食可能是人类癌症发病因素之一的观点提供了一些支持。
