Kirkpatrick C J, Mohr W, Haferkamp O
Rheumatol Int. 1981;1(3):131-3. doi: 10.1007/BF00541257.
The effects of soluble monosodium urate (350, 50, and 5 mumol/l) on the proliferation and proteoglycan synthesis of lapine articular chondrocytes were studied in a monolayer culture system. Cellular proliferation in vitro was unaffected by urate treatment. Chondrocytes treated with 50 mumol/l sodium urate showed a 26% reduction in binding of 35SO4 to matrix macromolecules. However, this reduction did not achieve statistical significance. The 350 and 5 mumol/l concentrations did not alter 35SO4 binding. It is proposed that monosodium urate has no marked direct effect on chondrocyte viability, proliferation and proteoglycan synthesis.
在单层培养系统中研究了可溶性尿酸钠（350、50和5μmol/L）对兔关节软骨细胞增殖和蛋白聚糖合成的影响。尿酸处理对体外细胞增殖没有影响。用50μmol/L尿酸钠处理的软骨细胞，其35SO4与基质大分子的结合减少了26%。然而，这种减少没有达到统计学显著性。350和5μmol/L的浓度没有改变35SO4的结合。有人提出，尿酸钠对软骨细胞活力、增殖和蛋白聚糖合成没有明显的直接影响。
