Galegov G A, Knight V, Pushkarskaia N L, Wilson S Z, Couch R B
Vopr Virusol. 1981 Nov-Dec(6):697-701.
The inhibiting effect of remantadine (amantadine) and ribavirin combination on experimental influenza infection was studied in comparison of the effect of each of these drugs alone. The combination of the two chemopreparations was found to inhibit synthesis of influenza A virus proteins in cell culture more effectively, to ensure maximum survival rate of white mice treated with these preparations by oral, aerosol and intraperitoneal routes of administration.
对金刚乙胺(金刚烷胺)与利巴韦林联合用药对实验性流感感染的抑制作用进行了研究,并与这两种药物单独使用的效果进行了比较。发现这两种化学制剂联合使用时,在细胞培养中能更有效地抑制甲型流感病毒蛋白的合成,通过口服、气溶胶吸入和腹腔注射途径给药时,能确保用这些制剂治疗的小白鼠的最大存活率。