Wilson S Z, Knight V, Wyde P R, Drake S, Couch R B
Antimicrob Agents Chemother. 1980 Apr;17(4):642-8. doi: 10.1128/AAC.17.4.642.
Ribavirin, amantadine, and the two drugs in combination given in small-particle aerosol were highly effective in the treatment of influenza A infection in mice. Treatment was started 72, 96, and 120 h after inoculation and was given continuously for 4 days. With increasing delay in start of treatment, there was a pronounced reduction in effectiveness of ribavirin but not in that of amantadine. The combination treatment reflected the loss of ribavirin activity. Leukocyte infiltration and virus titers in the lungs were inversely related to the effectiveness of treatment. Influenza B infection treated 72 h after inoculation responded only to ribavirin, as indicated by the criteria described for influenza A. Intraperitoneal administration of drug begun 72 h after inoculation in regimens equivalent to aerosol afforded less protection than aerosol treatment.
利巴韦林、金刚烷胺以及这两种药物以小颗粒气雾剂联合给药，对治疗小鼠甲型流感感染非常有效。在接种后72、96和120小时开始治疗，并持续给药4天。随着治疗开始时间的延迟增加，利巴韦林的有效性显著降低，但金刚烷胺的有效性并未降低。联合治疗反映了利巴韦林活性的丧失。肺中的白细胞浸润和病毒滴度与治疗效果呈负相关。接种后72小时治疗的乙型流感感染仅对利巴韦林有反应，这与针对甲型流感描述的标准一致。在接种后72小时开始以与气雾剂等效的方案进行腹腔内给药，其提供的保护比气雾剂治疗少。
