金刚烷胺和利巴韦林气雾剂对小鼠甲型和乙型流感感染的治疗作用
Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice.
作者信息
Wilson S Z, Knight V, Wyde P R, Drake S, Couch R B
出版信息
Antimicrob Agents Chemother. 1980 Apr;17(4):642-8. doi: 10.1128/AAC.17.4.642.
Abstract
Ribavirin, amantadine, and the two drugs in combination given in small-particle aerosol were highly effective in the treatment of influenza A infection in mice. Treatment was started 72, 96, and 120 h after inoculation and was given continuously for 4 days. With increasing delay in start of treatment, there was a pronounced reduction in effectiveness of ribavirin but not in that of amantadine. The combination treatment reflected the loss of ribavirin activity. Leukocyte infiltration and virus titers in the lungs were inversely related to the effectiveness of treatment. Influenza B infection treated 72 h after inoculation responded only to ribavirin, as indicated by the criteria described for influenza A. Intraperitoneal administration of drug begun 72 h after inoculation in regimens equivalent to aerosol afforded less protection than aerosol treatment.
摘要
利巴韦林、金刚烷胺以及这两种药物以小颗粒气雾剂联合给药，对治疗小鼠甲型流感感染非常有效。在接种后72、96和120小时开始治疗，并持续给药4天。随着治疗开始时间的延迟增加，利巴韦林的有效性显著降低，但金刚烷胺的有效性并未降低。联合治疗反映了利巴韦林活性的丧失。肺中的白细胞浸润和病毒滴度与治疗效果呈负相关。接种后72小时治疗的乙型流感感染仅对利巴韦林有反应，这与针对甲型流感描述的标准一致。在接种后72小时开始以与气雾剂等效的方案进行腹腔内给药，其提供的保护比气雾剂治疗少。
相似文献
1
Amantadine and ribavirin aerosol treatment of influenza A and B infection in mice.金刚烷胺和利巴韦林气雾剂对小鼠甲型和乙型流感感染的治疗作用
Antimicrob Agents Chemother. 1980 Apr;17(4):642-8. doi: 10.1128/AAC.17.4.642.
2
[Combined action of remantadine (amantadine) and ribavirin on experimental influenza].[金刚乙胺（金刚烷胺）与利巴韦林对实验性流感的联合作用]
Vopr Virusol. 1981 Nov-Dec(6):697-701.
3
Therapeutic effects of ribavirin given by the intraperitoneal or aerosol route against influenza virus infections in mice.腹腔内或雾化途径给予利巴韦林对小鼠流感病毒感染的治疗效果。
Antimicrob Agents Chemother. 1976 Sep;10(3):549-54. doi: 10.1128/AAC.10.3.549.
4
Response of influenza virus-infected mice to selected doses of ribavirin administered intraperitoneally or by aerosol.流感病毒感染小鼠对腹腔注射或雾化吸入特定剂量利巴韦林的反应。
Antimicrob Agents Chemother. 1977 Jun;11(6):1069-70. doi: 10.1128/AAC.11.6.1069.
5
Small-particle aerosols of antiviral compounds in treatment of type A influenza pneumonia in mice.抗病毒化合物的小颗粒气溶胶对小鼠甲型流感肺炎的治疗作用
J Infect Dis. 1976 Jun;133 Suppl:A140-4. doi: 10.1093/infdis/133.supplement_2.a140.
6
Lack of interference of guanosine with ribavirin aerosol treatment of influenza A infection in mice.鸟苷对小鼠甲型流感感染的利巴韦林气雾剂治疗无干扰作用。
Antimicrob Agents Chemother. 1981 Oct;20(4):477-80. doi: 10.1128/AAC.20.4.477.
7
Ribavirin small-particle aerosol treatment of influenza.利巴韦林小颗粒气雾剂治疗流感。
Lancet. 1981 Oct 31;2(8253):945-9. doi: 10.1016/s0140-6736(81)91152-1.
8
Protection of mice from lethal influenza virus infection with high dose-short duration ribavirin aerosol.高剂量-短疗程利巴韦林气雾剂对小鼠致死性流感病毒感染的保护作用。
Antimicrob Agents Chemother. 1986 Dec;30(6):942-4. doi: 10.1128/AAC.30.6.942.
9
Activity of amantadine, rimantadine, and ribavirin against swine influenza in mice and squirrel monkeys.金刚烷胺、盐酸金刚乙胺和利巴韦林对小鼠和松鼠猴感染的猪流感病毒的活性。
Antimicrob Agents Chemother. 1978 Feb;13(2):284-8. doi: 10.1128/AAC.13.2.284.
10
Efficacy of combined therapy with amantadine, oseltamivir, and ribavirin in vivo against susceptible and amantadine-resistant influenza A viruses.联合应用金刚烷胺、奥司他韦和利巴韦林对敏感和金刚烷胺耐药的甲型流感病毒进行体内治疗的效果。
PLoS One. 2012;7(1):e31006. doi: 10.1371/journal.pone.0031006. Epub 2012 Jan 23.
引用本文的文献
1
SARS-CoV-2 RNA-dependent RNA polymerase as a therapeutic target for COVID-19.SARS-CoV-2 依赖 RNA 的 RNA 聚合酶作为 COVID-19 的治疗靶点。
Expert Opin Ther Pat. 2021 Apr;31(4):325-337. doi: 10.1080/13543776.2021.1880568. Epub 2021 Mar 3.
2
Inhibition of Influenza Virus Polymerase by Interfering with Its Protein-Protein Interactions.通过干扰流感病毒聚合酶的蛋白质-蛋白质相互作用来抑制该病毒
ACS Infect Dis. 2021 Jun 11;7(6):1332-1350. doi: 10.1021/acsinfecdis.0c00552. Epub 2020 Oct 12.
3
Nucleosides for the treatment of respiratory RNA virus infections.用于治疗呼吸道RNA病毒感染的核苷。
Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618764483. doi: 10.1177/2040206618764483.
4
Inhaled anti-infective chemotherapy for respiratory tract infections: successes, challenges and the road ahead.用于呼吸道感染的吸入式抗感染化疗：成就、挑战与未来之路。
Adv Drug Deliv Rev. 2015 May;85:65-82. doi: 10.1016/j.addr.2014.11.004. Epub 2014 Nov 12.
5
How to approach and treat viral infections in ICU patients.如何诊治重症监护病房患者的病毒感染。
BMC Infect Dis. 2014 Nov 28;14:321. doi: 10.1186/1471-2334-14-321.
6
Antiviral combinations for severe influenza.用于重症流感的抗病毒联合疗法。
Lancet Infect Dis. 2014 Dec;14(12):1259-70. doi: 10.1016/S1473-3099(14)70821-7. Epub 2014 Sep 8.
7
Innovations in modeling influenza virus infections in the laboratory.实验室中流感病毒感染建模的创新。
Trends Microbiol. 2012 Jun;20(6):275-81. doi: 10.1016/j.tim.2012.03.006. Epub 2012 Apr 19.
8
Combination chemotherapy for influenza.流感的联合化疗。
Viruses. 2010 Aug;2(8):1510-1529. doi: 10.3390/v2081510. Epub 2010 Jul 27.
9
Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice.奥司他韦-利巴韦林联合疗法治疗小鼠高致病性H5N1流感病毒感染
Antimicrob Agents Chemother. 2008 Nov;52(11):3889-97. doi: 10.1128/AAC.01579-07. Epub 2008 Aug 25.
10
Respiratory viruses other than influenza virus: impact and therapeutic advances.除流感病毒外的呼吸道病毒：影响与治疗进展
Clin Microbiol Rev. 2008 Apr;21(2):274-90, table of contents. doi: 10.1128/CMR.00045-07.
本文引用的文献
1
Gas-chromatographic determination of amantadine in human urine.气相色谱法测定人尿中的金刚烷胺。
Clin Chem. 1980 Feb;26(2):295-6.
2
Measurement of respiratory volume for virus retention studies in mice.用于小鼠病毒滞留研究的呼吸量测量。
Appl Microbiol. 1972 Nov;24(5):812-8. doi: 10.1128/am.24.5.812-818.1972.
3
Small-particle aerosols of antiviral compounds in treatment of type A influenza pneumonia in mice.抗病毒化合物的小颗粒气溶胶对小鼠甲型流感肺炎的治疗作用
J Infect Dis. 1976 Jun;133 Suppl:A140-4. doi: 10.1093/infdis/133.supplement_2.a140.
4
Combined action of ribovirin and rimantadine in experimental myxovirus infection.利巴韦林与金刚乙胺在实验性黏液病毒感染中的联合作用
Experientia. 1977 Jul 15;33(7):905-6. doi: 10.1007/BF01951273.
5
Continuous aerosol therapy system using a modified Collison nebulizer.使用改良型科里森雾化器的连续气溶胶治疗系统。
J Clin Microbiol. 1977 Feb;5(2):131-6. doi: 10.1128/jcm.5.2.131-136.1977.
6
Morphological and cytochemical characterization of cells infiltrating mouse lungs after influenza infection.流感感染后浸润小鼠肺部细胞的形态学和细胞化学特征
Infect Immun. 1978 Jul;21(1):140-6. doi: 10.1128/iai.21.1.140-146.1978.
7
Amantadine aerosol in humans.人体中的金刚烷胺气雾剂。
Antimicrob Agents Chemother. 1979 Nov;16(5):572-8. doi: 10.1128/AAC.16.5.572.
8
Amantadine small-particle aerosol: generation and delivery to man.
Proc Soc Exp Biol Med. 1979 Jul;161(3):350-4. doi: 10.3181/00379727-161-40551.
9
Inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride.盐酸金刚烷胺对人淋巴细胞体外增殖反应的抑制作用。
Infect Immun. 1979 Mar;23(3):665-9. doi: 10.1128/iai.23.3.665-669.1979.
10
Comparison of different tissue cultures for isolation and quantitation of influenza and parainfluenza viruses.用于流感病毒和副流感病毒分离及定量的不同组织培养方法的比较
J Clin Microbiol. 1979 Jul;10(1):32-6. doi: 10.1128/jcm.10.1.32-36.1979.
Zotero 插件