Taylor R, Zimmet P
Diabetes Care. 1981 Sep-Oct;4(5):556-8. doi: 10.2337/diacare.4.5.556.
We have analyzed data from 3370 OGTTs performed during epidemiologic studies in three different ethnic groups (Micronesian, Polynesian, and Melanesian) in various Pacific countries to examine the value of a single fasting plasma glucose greater than or equal to 140 mg/dl as a diagnostic test for diabetes (defined as 2-h plasma glucose greater than or equal to 200 mg/dl). A fasting plasma glucose greater than or equal to 140 mg/dl is a highly specific test for diabetes, specificity in the various populations ranging from 98.1% to 99.7%. On the other hand, the sensitivity of fasting plasma glucose was not high and varied greatly between the populations (46.2%-79.0%). The predictive value of fasting plasma glucose for the diagnosis of diabetes was lowest in populations with a low diabetes prevalence and improved in higher prevalence groups. These data indicate that a fasting plasma glucose greater than or equal to 140 mg/dl is not a good screening test, apart from populations with a high prevalence of diabetes mellitus, and the 2-h postload plasma glucose is preferable.
我们分析了在太平洋地区不同国家的三个不同种族群体（密克罗尼西亚人、波利尼西亚人和美拉尼西亚人）的流行病学研究期间进行的3370次口服葡萄糖耐量试验（OGTT）的数据，以检验空腹血糖大于或等于140mg/dl作为糖尿病诊断试验（定义为2小时血糖大于或等于200mg/dl）的价值。空腹血糖大于或等于140mg/dl是一种对糖尿病具有高度特异性的检测方法，在不同人群中的特异性范围为98.1%至99.7%。另一方面，空腹血糖的敏感性不高，且在不同人群之间差异很大（46.2%-79.0%）。空腹血糖对糖尿病诊断的预测价值在糖尿病患病率低的人群中最低，而在患病率较高的人群中有所提高。这些数据表明，除了糖尿病患病率高的人群外，空腹血糖大于或等于140mg/dl不是一个好的筛查试验，餐后2小时血糖更可取。
