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金黄色葡萄球菌临床菌株中不存在对红霉素耐药性突变的证据。

Lack of evidence for mutation to erythromycin resistance in clinical strains of Staphylococcus aureus.

作者信息

Lacey R W

出版信息

J Clin Pathol. 1977 Jul;30(7):602-5. doi: 10.1136/jcp.30.7.602.

DOI:10.1136/jcp.30.7.602
PMID:886013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC476494/
Abstract

The properties of 100 erythromycin resistant strains of Staphylococcus aureus obtained from clinical material have been compared with the properties of mutants selected in vitro for resistance to erythromycin. The properties, including inducibility of the resistance and cross-resistance to spiramycin and lincomycin, of the two groups of isolates were always different. The risk that staphylococci will mutate to erythromycin resistance during therapy with this antibiotic is remote.

摘要

对从临床材料中分离得到的100株耐红霉素金黄色葡萄球菌的特性，与体外筛选出的耐红霉素突变株的特性进行了比较。两组分离株的特性，包括耐药性的诱导性以及对螺旋霉素和林可霉素的交叉耐药性，始终存在差异。葡萄球菌在使用这种抗生素治疗期间突变为耐红霉素的风险很小。

相似文献

1
Lack of evidence for mutation to erythromycin resistance in clinical strains of Staphylococcus aureus.金黄色葡萄球菌临床菌株中不存在对红霉素耐药性突变的证据。
J Clin Pathol. 1977 Jul;30(7):602-5. doi: 10.1136/jcp.30.7.602.
2
Sub-inhibitory and post-antibiotic effects of spiramycin and erythromycin on Staphylococcus aureus.螺旋霉素和红霉素对金黄色葡萄球菌的亚抑菌作用及抗生素后效应
J Antimicrob Chemother. 1988 Jul;22 Suppl B:33-9. doi: 10.1093/jac/22.supplement_b.33.
3
Alteration of 23 S ribosomal RNA and erythromycin-induced resistance to lincomycin and spiramycin in Staphylococcus aureus.金黄色葡萄球菌中23S核糖体RNA的改变及红霉素诱导的对林可霉素和螺旋霉素的耐药性
J Mol Biol. 1973 Feb 15;74(1):67-72. doi: 10.1016/0022-2836(73)90355-0.
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Medical implications of macrolide resistance and its relationship to the use of tylosin in animal feeds.
Infection. 1977;5(3):137-9. doi: 10.1007/BF01639747.
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[Inducibility of 1-step and multi-step resistance in Staphylococcus aureus strains].
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[Experimental research on microbiological profile of josamycin. II: Findings on the phenomenon of resistance in comparison with other macrolides].交沙霉素微生物学特征的实验研究。II：与其他大环内酯类药物相比的耐药现象研究结果
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Mutant of Staphylococcus aureus with lincomycin- and carbomycin-inducible resistance to erythromycin.对林可霉素和碳霉素诱导的红霉素耐药的金黄色葡萄球菌突变体。
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Mitochondrial antibiotic resistance in yeast: ribosomal mutants resistant to chloramphenicol, erythromycin and spiramycin.酵母中的线粒体抗生素抗性：对氯霉素、红霉素和螺旋霉素耐药的核糖体突变体。
Biochim Biophys Acta. 1973 Jun 23;312(2):358-67. doi: 10.1016/0005-2787(73)90380-8.
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Macrolide resistance in Staphylococcus aureus. Relation between spiramycin-binding to ribosome and inhibition of polypeptide synthesis in a heat inducible-resistant mutant.金黄色葡萄球菌中的大环内酯抗性。螺旋霉素与核糖体结合及对热诱导抗性突变体中多肽合成抑制之间的关系。
Jpn J Microbiol. 1970 Mar;14(2):155-62.
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[Comparison of the in vitro post-antibiotic effect of C14 macrolides (erythromycin and roxithromycin) and C16 macrolides (josamycin and spiramycin) against Staphylococcus aureus].[C14 大环内酯类抗生素（红霉素和罗红霉素）与 C16 大环内酯类抗生素（交沙霉素和螺旋霉素）对金黄色葡萄球菌的体外抗生素后效应比较]
Pathol Biol (Paris). 1989 May;37(5):375-7.

本文引用的文献

1
INDUCIBLE RESISTANCE TO ERYTHROMYCIN IN STAPHYLOCOCCUS AUREUS.金黄色葡萄球菌对红霉素的诱导抗性
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The erythromycin group of antibiotics.红霉素类抗生素。
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Transfer of chromosomal genes between staphylococci in mixed cultures.混合培养物中葡萄球菌之间染色体基因的转移。
J Gen Microbiol. 1972 Jul;71(2):399-401. doi: 10.1099/00221287-71-2-399.
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Cultural characters of a newly recognized group of hospital staphylococci.一组新发现的医院葡萄球菌的培养特性
J Clin Pathol. 1966 Jul;19(4):305-12. doi: 10.1136/jcp.19.4.305.
5
Antibiotic resistance plasmids of Staphylococcus aureus and their clinical importance.金黄色葡萄球菌的抗生素耐药质粒及其临床重要性。
Bacteriol Rev. 1975 Mar;39(1):1-32. doi: 10.1128/br.39.1.1-32.1975.
6
Variation in the properties of a strain of Staphylococcus aureus isolated over three months from a single hospital.
J Med Microbiol. 1975 Feb;8(1):39-46. doi: 10.1099/00222615-8-1-39.