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金黄色葡萄球菌临床菌株中不存在对红霉素耐药性突变的证据。

Lack of evidence for mutation to erythromycin resistance in clinical strains of Staphylococcus aureus.

作者信息

Lacey R W

出版信息

J Clin Pathol. 1977 Jul;30(7):602-5. doi: 10.1136/jcp.30.7.602.

Abstract

The properties of 100 erythromycin resistant strains of Staphylococcus aureus obtained from clinical material have been compared with the properties of mutants selected in vitro for resistance to erythromycin. The properties, including inducibility of the resistance and cross-resistance to spiramycin and lincomycin, of the two groups of isolates were always different. The risk that staphylococci will mutate to erythromycin resistance during therapy with this antibiotic is remote.

摘要

对从临床材料中分离得到的100株耐红霉素金黄色葡萄球菌的特性,与体外筛选出的耐红霉素突变株的特性进行了比较。两组分离株的特性,包括耐药性的诱导性以及对螺旋霉素和林可霉素的交叉耐药性,始终存在差异。葡萄球菌在使用这种抗生素治疗期间突变为耐红霉素的风险很小。

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