Kuno K, Fukami A, Hori M, Kasumi F
Breast Cancer Res Treat. 1981;1(2):135-9. doi: 10.1007/BF01805867.
An association between hormone receptors in primary breast cancer and obesity determined prior to mastectomy was investigated in 128 Japanese women. The following criteria for obesity were used: (1) weight greater than or equal to 60 kg (132 lbs), (2) weight kg/height cm-105 greater than or equal to 1.3, (3) weight lbs/height in greater than or equal to 2.30, (4) body surface area greater than or equal to 1.56 m2. In view of the 4 criteria, tumor estrogen receptor (ER) values greater than or equal to 4 fmol/mg were observed in obese patients more often than in nonobese patients, though the difference was not statistically significant. The same tendency was observed in the postmenopausal subgroup, 62 patients, especially in the 36 patients more than 5 years beyond menopause. However, there was still no statistical difference between obese and nonobese patients because the number of subjects was small. The same tendency was observed in the case of progesterone receptor (PgR) (greater than or equal to 6 fmol/mg) as observed in the case of ER.
对128名日本女性进行了研究，调查了乳房切除术之前确定的原发性乳腺癌激素受体与肥胖之间的关联。采用了以下肥胖标准：（1）体重≥60千克（132磅）；（2）体重（千克）/身高（厘米）-105≥1.3；（3）体重（磅）/身高（英寸）≥2.30；（4）体表面积≥1.56平方米。根据这4项标准，肥胖患者的肿瘤雌激素受体（ER）值≥4飞摩尔/毫克的情况比非肥胖患者更常见，尽管差异无统计学意义。在62名绝经后亚组患者中观察到了相同的趋势，尤其是在绝经超过5年的36名患者中。然而，由于受试者数量较少，肥胖患者与非肥胖患者之间仍无统计学差异。在孕激素受体（PgR）（≥6飞摩尔/毫克）的情况中观察到了与ER情况相同的趋势。
